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Article

Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation.

The Journal of cell biology - 11 Oct 2004

Grossmann Katja S, Grund Christine, Huelsken Joerg, Behrend Martin, Erdmann Bettina, Franke Werner W, Birchmeier Walter

Abstract excerpt

Plakophilins are proteins of the armadillo family that function in embryonic development and in the adult, and when mutated can cause disease. We have ablated the plakophilin 2 gene in mice. The resulting mutant mice exhibit lethal alterations in heart morphogenesis and stability at mid-gestation (E10.5-E11), characterized by reduced trabeculation, disarrayed cytoskeleton, ruptures of cardiac walls, and blood...

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Identifiers

PMID: 15479741
DOI: 10.1083/jcb.200402096
PMCID: PMC2172504

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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