Article
Analysis of quantitative trait loci for blood pressure on rat chromosomes 2 and 13. Age-related differences in effect.
Hypertension (Dallas, Tex. : 1979) - 1 Dec 1996
Samani N J, Gauguier D, Vincent M, Kaiser M A, Bihoreau M T, Lodwick D, Wallis R, Parent V, Kimber P, Rattray F, Thompson J R, Sassard J, Lathrop M
Abstract excerpt
Previous studies have suggested the presence of quantitative trait loci (QTLs) influencing blood pressure on rat chromosomes 2 and 13. In this study, we mapped the QTLs in F2 rats derived from a cross of the spontaneously hypertensive rat and the Wistar-Kyoto rat and analyzed the effect of the QTLs on blood pressures measured longitudinally between 12 and 25 weeks of age. We analyzed 16 polymorphic markers...
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