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Article

Structural basis of antibody-antigen interactions.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2009

Sundberg Eric J

Abstract excerpt

Antibody molecules can be regarded as products of a protein engineering system for the generation of a virtually unlimited repertoire of complementary molecular surfaces. This extreme structural heterogeneity is required for recognition of the nearly infinite array of antigenic determinants. This chapter discusses the structures of antibodies and their specific recognition of antigens, the binding energetics of...

Topics

Animals
Antibodies
Antigen-Antibody Complex
Antigens
Binding Sites, Antibody
Cross Reactions
Crystallography, X-Ray
Humans
Mutation
Protein Conformation
Thermodynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19377934
DOI: 10.1007/978-1-59745-450-6_2

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