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Article

Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system.

Molecular and cellular biology - 1 Feb 2003

MacPherson D, Sage J, Crowley D, Trumpp A, Bronson R T, Jacks T

Abstract excerpt

Targeted disruption of the retinoblastoma gene in mice leads to embryonic lethality in midgestation accompanied by defective erythropoiesis. Rb(-/-) embryos also exhibit inappropriate cell cycle activity and apoptosis in the central nervous system (CNS), peripheral nervous system (PNS), and ocular lens. Loss of p53 can prevent the apoptosis in the CNS and lens; however, the specific signals leading to p53...

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Identifiers

PMID: 12529408
DOI: 10.1128/MCB.23.3.1044-1053.2003
PMCID: PMC140709

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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