Article
Caspase 3 deficiency rescues peripheral nervous system defect in retinoblastoma nullizygous mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Sept 2001
Simpson M T, MacLaurin J G, Xu D, Ferguson K L, Vanderluit J L, Davoli M A, Roy S, Nicholson D W, Robertson G S, Park D S, Slack R S
Abstract excerpt
The retinoblastoma tumor suppressor protein, pRb, is a key regulator of cell cycle and has been implicated in the terminal differentiation of neuronal cells. Mice nullizygous for pRb die by embryonic day 14.5 from hematopoietic and neurological defects attributed to failed differentiation (Clarke et al., 1992; Jacks et al., 1992; Lee et al., 1992). Previous studies by MacLeod et al. (1996) have demonstrated that...
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