Article
Dominant interfering alleles define a role for c-Myb in T-cell development.
Genes & development - 1 Apr 1994
Badiani P, Corbella P, Kioussis D, Marvel J, Weston K
Abstract excerpt
The transcription activator c-Myb is expressed at high levels in immature thymocytes and during T-cell activation and may be a regulator of T-cell differentiation. To investigate the role of c-Myb in T-cell development, we generated transgenic mice in which two dominant interfering Myb alleles, o...
Topics
- Alleles
- Animals
- Base Sequence
- Cell Differentiation
- Cell Division
- DNA-Binding Proteins
- Drosophila
- Drosophila Proteins
- Gene Expression Regulation, Developmental
- Genes, Dominant
- Homeodomain Proteins
- Insect Hormones
- Lymphocyte Activation
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-myb