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Article

Paired TCRαβ analysis of virus-specific CD8(+) T cells exposes diversity in a previously defined 'narrow' repertoire.

Immunology and cell biology - 1 Oct 2015

Cukalac Tania, Kan Wan-Ting, Dash Pradyot, Guan Jing, Quinn Kylie M, Gras Stephanie, Thomas Paul G, La Gruta Nicole L

Abstract excerpt

T-cell receptor (TCR) usage has an important role in determining the outcome of CD8(+) cytotoxic T-lymphocyte responses to viruses and other pathogens. However, the characterization of TCR usage from which such conclusions are drawn is based on exclusive analysis of either the TCRα chain or, more commonly, the TCRβ chain. Here, we have used a multiplexed reverse transcription-PCR protocol to analyse the CDR3...

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Topics

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Share to CD8-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Complementarity Determining Regions

Share to Epitopes, T-Lymphocyte

Share to Influenza A Virus, H3N2 Subtype

Share to Orthomyxoviridae Infections

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to T-Lymphocytes, Cytotoxic

Source

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Identifiers

PMID: 25804828
DOI: 10.1038/icb.2015.44
PMCID: PMC4618100

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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