Article
Immunodominance correlates with T-cell receptor (alpha beta) gene usage in the class II-restricted response to influenza haemagglutinin.
Immunology - 1 Jul 1994
Smith C A, Graham C M, Thomas D B
Abstract excerpt
Class II-restricted T-cell clones elicited by natural infection with influenza A virus (H3N2 subtype) exhibit extensive diversity in their recognition specificity for the envelope glycoprotein, haemagglutinin, and focus on hypervariable regions of the HA1 subunit that feature in antigenic drift....
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- CD4-Positive T-Lymphocytes
- Cells, Cultured
- Clone Cells
- Gene Rearrangement, T-Lymphocyte
- Genetic Variation
- Hemagglutinin Glycoproteins, Influenza Virus
- Hemagglutinins, Viral
- Histocompatibility Antigens Class II
- Influenza A virus
- Mice
- Mice, Inbred BALB C
- Mice, Inbred CBA
- Molecular Sequence Data
- Orthomyxoviridae Infections
- Polymerase Chain Reaction