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CD8+ TCR Repertoire Formation Is Guided Primarily by the Peptide Component of the Antigenic Complex

25 Dec 2012

Abstract excerpt

CD8(+) T cells recognize infected or dysregulated cells via the clonotypically expressed αβ TCR, which engages Ag in the form of peptide bound to MHC class I (MHC I) on the target cell surface. Previous studies have indicated that a diverse Ag-specific TCR repertoire can be beneficial to the host, yet the determinants of clonotypic diversity are poorly defined. To better understand the factors that govern TCR...

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PMID: 23267020
DOI: 10.4049/jimmunol.1202466

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