Article
Modulation of HLA-DQ binding properties by differences in class II dimer stability and pH-dependent peptide interactions.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 1996
Buckner J, Kwok W W, Nepom B, Nepom G T
Abstract excerpt
Intermolecular interactions between peptides and class II molecules intracellularly are likely to be influenced by different pH conditions in different endosomal compartments. We compared the pH-dependent binding of peptides to HLA-DQ alleles 3.1 and 3.2, two well-studied human class II molecules with limited structural variability but different genetic associations with autoimmune diseases. Binding of the...
Topics
- Alleles
- Amino Acid Sequence
- Antigens, Differentiation, B-Lymphocyte
- Drug Stability
- HLA-DQ Antigens
- Histocompatibility Antigens Class II
- Humans
- Hydrogen-Ion Concentration
- In Vitro Techniques
- Models, Molecular
- Molecular Sequence Data
- Peptides
- Protein Binding
- Protein Conformation