Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modulation of HLA-DQ binding properties by differences in class II dimer stability and pH-dependent peptide interactions.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 1996

Buckner J, Kwok W W, Nepom B, Nepom G T

Abstract excerpt

Intermolecular interactions between peptides and class II molecules intracellularly are likely to be influenced by different pH conditions in different endosomal compartments. We compared the pH-dependent binding of peptides to HLA-DQ alleles 3.1 and 3.2, two well-studied human class II molecules with limited structural variability but different genetic associations with autoimmune diseases. Binding of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Amino Acid Sequence
Share to HLA-DQ Antigens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to In Vitro Techniques

Share to Models, Molecular

Share to Molecular Sequence Data

Share to Protein Binding

Share to Protein Conformation

Source

Identifiers

PMID: 8943399

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modulation of HLA-DQ binding properties by differences in class II dimer stability and pH-dependent peptide interactions.PMID 8943399Read ↗

A computational docking study on the pH dependence of peptide binding to HLA-B27 sub-types differentially associated with ankylosing spondylitis.Semantic proximity Read ↗

Invariant-cognate peptide exchange restores class II dimer stability in HLA-DM mutants.Semantic proximity Read ↗

Association between HLA-DM and HLA-DR in vivo.Semantic proximity Read ↗

Modulation of peptide binding by HLA-B27 polymorphism in pockets A and B, and peptide specificity of B*2703.Semantic proximity Read ↗

Exceptional stability of the HLA-DQA1*0102/DQB1*0602 alpha beta protein dimer, the class II MHC molecule associated with protection from insulin-dependent diabetes mellitus.Semantic proximity Read ↗

DRB1*0301 molecules recognize a structural motif distinct from the one recognized by most DR beta 1 alleles.Semantic proximity Read ↗

Allelic differences in the relationship between proteasome activity and MHC class I peptide loading.Semantic proximity Read ↗

HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH.Semantic proximity Read ↗

Allele-specific motifs characterize HLA-DQ interactions with a diabetes-associated peptide derived from glutamic acid decarboxylase.Semantic proximity Read ↗

Analysis of two acidic P6 pocket residues in the pH dependency of peptide binding by I-E(k).Semantic proximity Read ↗

HLA-DQ polymorphisms are highly selective for peptide binding interactions.Semantic proximity Read ↗

Thermodynamic stability of HLA-B*2705. Peptide complexes. Effect of peptide and major histocompatibility complex protein mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.