Allelic differences in the relationship between proteasome activity and MHC class I peptide loading.

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Article

Allelic differences in the relationship between proteasome activity and MHC class I peptide loading.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 1998

Benham A M, Grommé M, Neefjes J

Abstract excerpt

MHC class I molecules are cell surface glycoproteins that play a pivotal role in the response to intracellular pathogens. The loading of MHC class I molecules with antigenic substrates takes place in the endoplasmic reticulum. This requires a functional TAP transporter, which translocates peptide...

Topics

Alleles
Cell Line
Cysteine Endopeptidases
Cysteine Proteinase Inhibitors
HLA-A Antigens
HLA-A11 Antigen
HLA-A3 Antigen
HeLa Cells
Histocompatibility Antigens Class I
Humans
Isoelectric Focusing
Multienzyme Complexes
Peptides
Proteasome Endopeptidase Complex

Source

Open in PubMed

Identifiers

PMID: 9647210

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9647210-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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