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Article

Allelic differences in the relationship between proteasome activity and MHC class I peptide loading.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 1998

Benham A M, Grommé M, Neefjes J

Abstract excerpt

MHC class I molecules are cell surface glycoproteins that play a pivotal role in the response to intracellular pathogens. The loading of MHC class I molecules with antigenic substrates takes place in the endoplasmic reticulum. This requires a functional TAP transporter, which translocates peptides into the endoplasmic reticulum from the cytosol. The generation of antigenic peptides from polypeptide precursors is...

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PMID: 9647210

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Allelic differences in the relationship between proteasome activity and MHC class I peptide loading.PMID 9647210Read ↗

Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing.Semantic proximity Read ↗

HLA-B27-restricted antigen presentation in the absence of tapasin reveals polymorphism in mechanisms of HLA class I peptide loading.Semantic proximity Read ↗

Allele-dependent processing pathways generate the endogenous human leukocyte antigen (HLA) class I peptide repertoire in transporters associated with antigen processing (TAP)-deficient cells.Semantic proximity Read ↗

The role of tapasin in MHC class 1 antigen presentationSemantic proximity Read ↗

Physical and functional association of the major histocompatibility complex class I heavy chain alpha3 domain with the transporter associated with antigen processing.Semantic proximity Read ↗

Cytosolic aminopeptidases influence MHC class I-mediated antigen presentation in an allele-dependent manner.Semantic proximity Read ↗

Quantitative and Qualitative Influences of Tapasin on the Class I Peptide RepertoireSemantic proximity Read ↗

Differences in the expression of human class I MHC alleles and their associated peptides in the presence of proteasome inhibitors.Semantic proximity Read ↗

The pathway for processing leader-derived peptides that regulate the maturation and expression of Qa-1b.Semantic proximity Read ↗

Identifying MHC class I epitopes by predicting the TAP transport efficiency of epitope precursors.Semantic proximity Read ↗

Application of one-dimensional isoelectric focusing to separate different major histocompatibility complex class I alleles and determine their allelic interactions with transporter associated with antigen processing (TAP).Semantic proximity Read ↗

Distinct functions of tapasin revealed by polymorphism in MHC class I peptide loading.Semantic proximity Read ↗

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