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Article

Association between HLA-DM and HLA-DR in vivo.

Immunity - 1 Jan 1996

Sanderson F, Thomas C, Neefjes J, Trowsdale J

Abstract excerpt

The exchange of HLA class II-associated invariant chain peptides (CLIP) for cognate peptide is catalyzed by HLA-DM under acidic conditions in vitro by an unknown mechanism. Here, we show an association between HLA-DM and HLA-DR in vivo by coprecipitation of the two heterodimers. The association is favored at low pH and in the nonionic detergent digitonin. Most DM-DR complexes are isolated from dense subcellular...

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Identifiers

PMID: 8574855
DOI: 10.1016/s1074-7613(00)80301-5

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