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Article

Targeted gene repair and its application to neurodegenerative disorders.

Neuron - 14 Feb 2002

Parekh-Olmedo Hetal, Krainc Dimitri, Kmiec Eric B

Abstract excerpt

Synthetic DNA oligonucleotides can direct the exchange of single nucleotides within coding regions of mammalian genes by hybridizing to their complementary sequence in the chromosome and creating a recombination joint structure with a single mismatched base pair. Inherent DNA repair processes recognize the mismatch and resolve it using the DNA sequence of the oligonucleotide vector as the template. This gene...

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PMID: 11856524
DOI: 10.1016/s0896-6273(02)00594-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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