Article
A family-based strategy to identify genes for diabetic nephropathy.
American journal of kidney diseases : the official journal of the National Kidney Foundation - 1 Mar 2001
Covic A M, Iyengar S K, Olson J M, Sehgal A R, Constantiner M, Jedrey C, Kara M, Sabbagh E, Sedor J R, Schelling J R
Abstract excerpt
Diabetic nephropathy (DN) clusters in families and specific ethnic groups, suggesting a genetic basis of disease transmission. Identification of DN susceptibility loci should reveal new therapeutic targets but requires accurate phenotyping. A powerful family-based strategy, which is novel to the pursuit of nephropathy genes in type 2 diabetes, is being used to collect a sample for candidate gene and genome scan...
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