Article
High-density single nucleotide polymorphism genome-wide linkage scan for susceptibility genes for diabetic nephropathy in type 1 diabetes: discordant sibpair approach.
Diabetes - 1 Sept 2008
Rogus John J, Poznik G David, Pezzolesi Marcus G, Smiles Adam M, Dunn Jonathon, Walker William, Wanic Krzysztof, Moczulski Dariusz, Canani Luis, Araki Shinichi, Makita Yuichiro, Warram James H, Krolewski Andrzej S
Abstract excerpt
OBJECTIVE: Epidemiological and family studies have demonstrated that susceptibility genes play an important role in the etiology of diabetic nephropathy, defined as persistent proteinuria or end-stage renal disease (ESRD) in type 1 diabetes. RESEARCH DESIGN AND METHODS: To efficiently search for genomic regions harboring diabetic nephropathy genes, we conducted a scan using 5,382 informative single nucleotide...
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