Article
Phenotypic and genotypic diversity of human neuroblastoma studied in three IGR cell line models derived from bone marrow metastases.
Cancer genetics and cytogenetics - 15 Jul 1999
Valent A, Bénard J, Vénuat A M, Silva J, Duverger A, Duarte N, Hartmann O, Spengler B A, Bernheim A
Abstract excerpt
Metastatic stage IV neuroblastoma tumors, as well as cell lines derived from them, are highly malignant and rapidly fatal. To determine whether malignant potential of these cells might be influenced by stromal tissue at sites frequently involved in metastasis, we initiated primary cultures from bone marrow of three patients (331, 337, and 91) with stage IV neuroblastoma. All three explants contained two distinct...
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