Article
Neuroblastic and Schwannian stromal cells of neuroblastoma are derived from a tumoral progenitor cell.
Cancer research - 15 Sept 2001
Mora J, Cheung N K, Juan G, Illei P, Cheung I, Akram M, Chi S, Ladanyi M, Cordon-Cardo C, Gerald W L
Abstract excerpt
The coexistence of neuroblastic and Schwannian stromal (SS) cells in differentiating neuroblastoma (NB), and derivation of Schwannian-like cells from neuroblastic clones in vitro, were accepted previously as evidence of a common pluripotent tumor stem line. This paradigm was challenged when SS cells were suggested to be reactive in nature. The advent of microdissection techniques, PCR-based allelic analysis, and...
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