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Article

Loss of the malignant phenotype of human neuroblastoma cells by a catalytically inactive dominant-negative hTERT mutant.

Molecular cancer therapeutics - 1 Nov 2012

Samy Mona, Gattolliat Charles-Henry, Pendino Frédéric, Hillion Josette, Nguyen Eric, Bombard Sophie, Douc-Rasy Sétha, Bénard Jean, Ségal-Bendirdjian Evelyne

Abstract excerpt

Telomerase, a ribonucleoprotein complex mainly composed of the reverse transcriptase catalytic subunit (human telomerase reverse transcriptase, hTERT) and the RNA component (hTR), is a key enzyme of cancer progression. That aggressive stage 4-neuroblastoma expressed high levels of telomerase activity, whereas favorable tumors had no or little telomerase expression and activity, prompted us to investigate the role...

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PMID: 22933702
DOI: 10.1158/1535-7163.MCT-12-0281

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MYCN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of the malignant phenotype of human neuroblastoma cells by a catalytically inactive dominant-negative hTERT mutant.PMID 22933702Read ↗

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