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Article

Id-1 Delays Senescence but Does Not Immortalize Keratinocytes

1 Sept 2000

Abstract excerpt

Defining the molecular basis responsible for regulating the proliferative potential of keratinocytes has important implications for normal homeostasis and neoplasia of the skin. Under current culture conditions, neonatal foreskin-derived human keratinocytes possess a relatively short replicative lifespan. Recently it was reported that forced overexpression of the helix-loop-helix protein Id-1 was capable of...

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PMID: 10908559
DOI: 10.1074/jbc.c000311200

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