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Article

Repression of c- <i>fos</i> Transcription and an Altered Genetic Program in Senescent Human Fibroblasts

12 Jan 1990

Abstract excerpt

Normal cells in culture invariably undergo senescence, whereby they cease proliferation after a finite number of doublings. Irreversible changes in gene expression occurred in senescent human fetal lung fibroblasts: a non-cell cycle-regulated mRNA was partially repressed; an unusual polyadenylated histone mRNA was expressed; although serum induced c-H-ras, c-myc, and ornithine decarboxylase mRNA normally,...

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Share to Advanced biosensing and bioanalysis techniques
Share to Epigenetics and DNA Methylation
Share to Telomeres, Telomerase, and Senescence

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PMID: 2104680
DOI: 10.1126/science.2104680

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