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Article

A novel transcriptional inhibitory element differentially regulates the cyclin D1 gene in senescent cells.

The Journal of biological chemistry - 28 Feb 2003

Berardi Philip, Meyyappan Muthupalaniappan, Riabowol Karl T

Abstract excerpt

Senescent human diploid fibroblasts are unable to initiate DNA synthesis following mitogenic stimulation and adopt a unique gene expression profile distinct from young or quiescent cells. In this study, a novel transcriptional regulatory element was identified in the 5'-untranslated region of the cyclin D1 gene. We show that this element differentially suppresses cyclin D1 expression in young versus senescent...

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PMID: 12464605
DOI: 10.1074/jbc.M210864200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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