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Replicative Senescence, Aging and Growth-Regulatory Transcription Factors

1 Jan 1996

Abstract excerpt

Normal somatic cells invariably enter a state of permanent growth arrest and altered function after a finite number of divisions. This phenomenon is termed cellular or replicative senescence. Replicative senescence is thought to be a tumor-suppressive mechanism, and a contributing factor in aging. Three features distinguish senescent from presenescent cells: an irreversible block to cell proliferation, increased...

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PMID: 8864060
DOI: 10.1159/000109185

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