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Article

Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen.

Experimental cell research - 1 Mar 1994

Noda A, Ning Y, Venable S F, Pereira-Smith O M, Smith J R

Abstract excerpt

We here describe a rapid and simple expression screen method that has allowed us to isolate cDNAs coding for inhibitors of DNA synthesis from senescent human diploid fibroblasts. The assay involved transient transcriptional overexpression of a gene product encoded by a cDNA in a proliferating cell, on the assumption that this would be sufficient to block DNA synthesis in a short-term assay using tritiated...

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Identifiers

PMID: 8125163
DOI: 10.1006/excr.1994.1063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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