Article
An increased NM23H1 copy number may be a poor prognostic factor independent of LOH on 1p in neuroblastomas.
British journal of cancer - 1 Nov 1996
Takeda O, Handa M, Uehara T, Maseki N, Sakashita A, Sakurai M, Kanda N, Arai Y, Kaneko Y
Abstract excerpt
In a study of 154 neuroblastomas, loss of heterozygosity (LOH) was observed on 1p (13%, 19/143), 11q (19%, 11/59), 14q (15%, 15/97), 17p (5%, 5/105) and 17q (17%, 9/52). We also found an increase in NM23H1 copy number in 14% (13/95) of neuroblastomas. All except one tumour with an increased copy number stained positive with anti-NM23H1 monoclonal antibody. Event-free survival (EFS) was significantly shorter in 19...
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