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Article

Allelic deletion at 11q23 is common in MYCN single copy neuroblastomas.

Oncogene - 2 Sept 1999

Guo C, White P S, Weiss M J, Hogarty M D, Thompson P M, Stram D O, Gerbing R, Matthay K K, Seeger R C, Brodeur G M, Maris J M

Abstract excerpt

Deletions of the long arm of chromosome 11 (11q) have been noted in primary neuroblastomas, but a comprehensive analysis has not been performed. Therefore, we analysed 331 neuroblastomas (295 sporadic, 15 familial and 21 tumor-derived cell lines) to determine the prevalence of 11q allelic deletions, to map the location of a putative tumor suppressor gene and to perform clinical correlative studies. Assays for...

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Topics

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Share to Chromosomes, Human, Pair 11
Share to Gene Amplification

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Dosage

Share to Genes, myc

Share to Genes, Tumor Suppressor

Share to Loss of Heterozygosity

Share to Neuroblastoma

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Source

Identifiers

PMID: 10490829
DOI: 10.1038/sj.onc.1202887

Genes

MYCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Allelic deletion at 11q23 is common in MYCN single copy neuroblastomas.PMID 10490829Read ↗

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Identification of a novel recurrent 1q42.2‐1qter deletion in high risk <i>MYCN</i> single copy 11q deleted neuroblastomasSemantic proximity Read ↗

Neuroblastomas with chromosome 11q loss and single copy MYCN comprise a biologically distinct group of tumours with adverse prognosisSemantic proximity Read ↗

Chromosome 1p and 11q Deletions and Outcome in NeuroblastomaSemantic proximity Read ↗

Comprehensive SNP array study of frequently used neuroblastoma cell lines; copy neutral loss of heterozygosity is common in the cell lines but uncommon in primary tumors.Semantic proximity Read ↗

High-resolution array copy number analyses for detection of deletion, gain, amplification and copy-neutral LOH in primary neuroblastoma tumors: four cases of homozygous deletions of the CDKN2A gene.Semantic proximity Read ↗

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Detailed deletion mapping of chromosome band 14q32 in human neuroblastoma defines a 1.1-Mb region of common allelic loss.Semantic proximity Read ↗

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