Article
Absence of the previously reported G protein oncogene (gip2) in ovarian granulosa cell tumors.
The Journal of clinical endocrinology and metabolism - 1 Nov 1996
Shen Y, Mamers P, Jobling T, Burger H G, Fuller P J
Abstract excerpt
The molecular pathogenesis of granulosa cell tumors of the ovary is not understood, although recent studies have shown that authentic inhibin secretion by these tumors may be used as a tumor marker. G proteins are heterotrimeric membrane-based polypeptides that mediate signal transduction. Activating mutations of the alpha-subunit have been reported in several tumors in which the resulting constitutively...
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