Article
Absence of the previously reported G protein oncogene (gip2) in ovarian granulosa cell tumors.
The Journal of clinical endocrinology and metabolism - 1 Nov 1996
Shen Y, Mamers P, Jobling T, Burger H G, Fuller P J
Abstract excerpt
The molecular pathogenesis of granulosa cell tumors of the ovary is not understood, although recent studies have shown that authentic inhibin secretion by these tumors may be used as a tumor marker. G proteins are heterotrimeric membrane-based polypeptides that mediate signal transduction. Activa...
Topics
- Adult
- Aged
- Aged, 80 and over
- Base Sequence
- DNA Primers
- DNA, Neoplasm
- Female
- GTP-Binding Protein alpha Subunit, Gi2
- GTP-Binding Protein alpha Subunits, Gi-Go
- GTP-Binding Proteins
- Granulosa Cell Tumor
- Humans
- Middle Aged
- Mutation
- Oncogenes
- Ovarian Neoplasms
- Polymerase Chain Reaction
- Proto-Oncogene Proteins