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Article

Analysis of mutations in genes of the follicle-stimulating hormone receptor signaling pathway in ovarian granulosa cell tumors.

The Journal of clinical endocrinology and metabolism - 1 Jun 1999

Ligtenberg M J, Siers M, Themmen A P, Hanselaar T G, Willemsen W, Brunner H G

Abstract excerpt

It has been suggested that ovarian granulosa cell tumors may result from unopposed hyperstimulation, either by excessive gonadotropin stimulation, by activating mutations of the FSH receptor gene, or of the G protein subunits, Gs alpha or Gi alpha2. We have examined the entire open reading frame...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10372736
DOI: 10.1210/jcem.84.6.5739

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10372736-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Analysis of mutations in genes of the follicle-stimulating hormone receptor signaling pathway in ovarian granulosa cell tumors.PMID 10372736Read ↗

No evidence of a role for mutations or polymorphisms of the follicle-stimulating hormone receptor in ovarian granulosa cell tumors.Semantic proximity Read ↗

Absence of the previously reported G protein oncogene (gip2) in ovarian granulosa cell tumors.Semantic proximity Read ↗

Expression status and mutational analysis of the PTEN and P13K subunit genes in ovarian granulosa cell tumors.Semantic proximity Read ↗

Expression status and mutational analysis of the ras and B-raf genes in ovarian granulosa cell and epithelial tumors.Semantic proximity Read ↗

Activating mutation of the stimulatory G protein (gsp) as a putative cause of ovarian and testicular human stromal Leydig cell tumors.Semantic proximity Read ↗

No evidence of somatic activating mutations on gonadotropin receptor genes in sex cord stromal tumors.Semantic proximity Read ↗

Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure.Semantic proximity Read ↗

A mutation in the follicle-stimulating hormone receptor occurs frequently in human ovarian sex cord tumors.Semantic proximity Read ↗

Pituitary adenomas: screening for G alpha q mutations.Semantic proximity Read ↗

Possible familial gestational spontaneous ovarian hyperstimulation syndrome due to mutation of FSH receptors (FGSOHS).Semantic proximity Read ↗

Mutation analysis of the growth differentiation factor-9 and -9B genes in patients with premature ovarian failure and polycystic ovary syndromeSemantic proximity Read ↗

Cell type-specific targeted mutations of Kras and Pten document proliferation arrest in granulosa cells versus oncogenic insult to ovarian surface epithelial cells.Semantic proximity Read ↗

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