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Article

Expression status and mutational analysis of the PTEN and P13K subunit genes in ovarian granulosa cell tumors.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 1 Apr 2009

Bittinger Sophie, Alexiadis Maria, Fuller Peter J

Abstract excerpt

Granulosa cell tumors (GCT) are a unique subset of ovarian tumors which have a molecular phenotype resembling that of follicle stimulating hormone (FSH)-stimulated pre-ovulatory granulosa cells. FSH acts via its receptor to stimulate signaling pathways including the phosphatidylinositol 3-kinase (PI3K)-AKT pathway. Activation of this pathway occurs in solid tumors, including ovarian epithelial tumors, through...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19407556
DOI: 10.1111/IGC.0b013e3181a1cdfd

Genes

PTEN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Expression status and mutational analysis of the PTEN and P13K subunit genes in ovarian granulosa cell tumors.PMID 19407556Read ↗

Molecular Pathogenesis of Granulosa Cell Tumors of the OvarySemantic proximity Read ↗

Expression status and mutational analysis of the ras and B-raf genes in ovarian granulosa cell and epithelial tumors.Semantic proximity Read ↗

Analysis of mutations in genes of the follicle-stimulating hormone receptor signaling pathway in ovarian granulosa cell tumors.Semantic proximity Read ↗

Impact of FOXL2 mutations on signaling in ovarian granulosa cell tumors.Semantic proximity Read ↗

PPP2R1A mutation is a rare event in ovarian carcinoma across histological subtypes.Semantic proximity Read ↗

Absence of the previously reported G protein oncogene (gip2) in ovarian granulosa cell tumors.Semantic proximity Read ↗

High Frequency of PIK3R1 Alterations in Ovarian Cancers: Clinicopathological and Molecular AssociationsSemantic proximity Read ↗

No evidence of a role for mutations or polymorphisms of the follicle-stimulating hormone receptor in ovarian granulosa cell tumors.Semantic proximity Read ↗

PI3K pathway in gynecologic malignancies.Semantic proximity Read ↗

Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis.Semantic proximity Read ↗

Frequent PTEN/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors.Semantic proximity Read ↗

Cell type-specific targeted mutations of Kras and Pten document proliferation arrest in granulosa cells versus oncogenic insult to ovarian surface epithelial cells.Semantic proximity Read ↗

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