Article
Expression status and mutational analysis of the ras and B-raf genes in ovarian granulosa cell and epithelial tumors.
Gynecologic oncology - 1 Dec 2004
Jamieson Stacey, Alexiadis Maria, Fuller Peter J
Abstract excerpt
OBJECTIVES: The molecular pathogenesis of granulosa cell tumors of the ovary (GCT) is not understood. Activating mutations in the K-, N-, and H-ras protooncogenes have been identified in a wide range of human cancers, including ovarian epithelial tumors. Furthermore, an apparent association has recently been reported between the presence of ras and B-raf mutations in the same cancer types. Activation of the...
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