Article
Activating mutation of the stimulatory G protein (gsp) as a putative cause of ovarian and testicular human stromal Leydig cell tumors.
The Journal of clinical endocrinology and metabolism - 1 Jun 1998
Fragoso M C, Latronico A C, Carvalho F M, Zerbini M C, Marcondes J A, Araujo L M, Lando V S, Frazzatto E T, Mendonca B B, Villares S M
Abstract excerpt
Activating mutations of the G protein genes have been associated with the development of several endocrine neoplasms. Such activating mutations, gip2, affecting the alpha-subunit of the G alpha i2 protein were previously described by a single group in 30% of ovarian sex cord stromal tumors. Other...
Topics
- Adolescent
- Adult
- Child
- DNA, Neoplasm
- Electrophoresis, Agar Gel
- Exons
- Female
- GTP-Binding Protein alpha Subunit, Gi2
- GTP-Binding Protein alpha Subunits, Gi-Go
- GTP-Binding Protein alpha Subunits, Gs
- GTP-Binding Proteins
- Humans
- Leydig Cell Tumor