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Article

Chlorambucil and bleomycin induce mutations in the specific-locus test in female mice.

Mutation research - 28 Oct 1996

Russell L B, Hunsicker P R, Shelby M D

Abstract excerpt

Specific-locus studies have shown chlorambucil (CHL) and bleomycin (BLE) to be mutagenic in mouse oocytes, almost doubling the number of chemicals previously known to induce mutations in females. The overall CHL-induced mutation rate in oocytes is, however, one order of magnitude below that for male meiotic and postmeiotic stages, and only 1/50 that for early spermatids. For BLE, no specific-locus data for males...

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Source

Identifiers

PMID: 8921974
DOI: 10.1016/0027-5107(96)00104-2

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