Discovery of numerous clusters of spontaneous mutations in the specific-locus test in mice necessitates major increases in estimates of doubling doses.

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Article

Discovery of numerous clusters of spontaneous mutations in the specific-locus test in mice necessitates major increases in estimates of doubling doses.

Genetica - 1 Jan 1998

Selby P B

Abstract excerpt

Both the precision with which mutations can be quickly identified and the extensive application of the method make results from specific-locus experiments in mice especially important for estimating the doubling dose, which is the radiation exposure that induces a mutation frequency equal to the...

Topics

Animals
Chromosome Mapping
Cluster Analysis
Computer Simulation
Dose-Response Relationship, Radiation
Female
Gamma Rays
Genes, Dominant
Genomic Imprinting
Humans
Male
Mice
Models, Genetic
Mosaicism
Mutagenesis
Mutation
Risk Factors
Sex Characteristics

Source

Open in PubMed

Identifiers

PMID: 9720295

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9720295-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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