Discovery of numerous clusters of spontaneous mutations in the specific-locus test in mice necessitates major increases in estimates of doubling doses.

Abstract excerpt

Both the precision with which mutations can be quickly identified and the extensive application of the method make results from specific-locus experiments in mice especially important for estimating the doubling dose, which is the radiation exposure that induces a mutation frequency equal to the total spontaneous mutation frequency per generation. Because of gonadal mosaicism and the mechanism by which it occurs,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Chromosome Mapping
• Share to Computer Simulation
• Share to Genes, Dominant