Article
Genetic and molecular analysis of chlorambucil-induced germ-line mutations in the mouse.
Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1990
Rinchik E M, Bangham J W, Hunsicker P R, Cacheiro N L, Kwon B S, Jackson I J, Russell L B
Abstract excerpt
Eighteen variants recovered from specific locus mutation rate experiments involving the mutagen chlorambucil were subjected to several genetic and molecular analyses. Most mutations were found to be homozygous lethal. Because lethality is often presumptive evidence for multilocus-deletion events,...
Topics
- Animals
- Blotting, Southern
- Chlorambucil
- Chromosome Deletion
- Crosses, Genetic
- Female
- Fertility
- Genetic Variation
- Heterozygote
- Homozygote
- Karyotyping
- Male
- Mice
- Mice, Inbred Strains
- Mutation
- Spermatids
- Spermatocytes
- Spermatogonia