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Article

ras mutations in endocrine tumors: mutation detection by polymerase chain reaction-single strand conformation polymorphism.

Japanese journal of cancer research : Gann - 1 Oct 1992

Yoshimoto K, Iwahana H, Fukuda A, Sano T, Katsuragi K, Kinoshita M, Saito S, Itakura M

Abstract excerpt

To elucidate the molecular basis for endocrine tumorigenesis, ras mutations in human endocrine tumors were analyzed using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis. Mutations of the H-, K-, N-ras genes were examined in genomic DNAs from 169 successfully amplified primary endocrine tumors out of 189 samples. Four out of 24 thyroid follicular adenomas analyzed contained...

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Identifiers

PMID: 1452458
DOI: 10.1111/j.1349-7006.1992.tb02722.x
PMCID: PMC5918679

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