ras mutations in endocrine tumors: mutation detection by polymerase chain reaction-single strand conformation polymorphism.

doi:10.1111/j.1349-7006.1992.tb02722.x

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Article

ras mutations in endocrine tumors: mutation detection by polymerase chain reaction-single strand conformation polymorphism.

Japanese journal of cancer research : Gann - 1 Oct 1992

Yoshimoto K, Iwahana H, Fukuda A, Sano T, Katsuragi K, Kinoshita M, Saito S, Itakura M

Abstract excerpt

To elucidate the molecular basis for endocrine tumorigenesis, ras mutations in human endocrine tumors were analyzed using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis. Mutations of the H-, K-, N-ras genes were examined in genomic DNAs from 169 successfully amplified primary endocrine tumors out of 189 samples. Four out of 24 thyroid follicular adenomas analyzed contained...

Topics

Adult
Base Sequence
Codon
DNA, Neoplasm
DNA, Single-Stranded
Endocrine Gland Neoplasms
Exons
Female
Gene Amplification
Genes, ras
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Molecular Sequence Data

Mutation

Nucleic Acid Conformation

Polymerase Chain Reaction

Polymorphism, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 1452458
DOI: 10.1111/j.1349-7006.1992.tb02722.x
PMCID: PMC5918679

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1452458-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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