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Article

Induction of apoptosis in rhabdomyosarcoma cells through down-regulation of PAX proteins

12 Nov 1996

Abstract excerpt

The expression of a number of human paired box-containing (PAX) genes has been correlated with various types of tumors. Novel fusion genes encoding chimeric fusion proteins have been found in the pediatric malignant tumor alveolar rhabdomyosarcoma (RMS). They are generated by two chromosomal translocations t(2;13) and t(1;13) juxtaposing PAX3 or PAX7, respectively, with a forkhead domain gene FKHR. Here we...

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PMID: 8917562
DOI: 10.1073/pnas.93.23.13164

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