Article
The role of chimeric paired box transcription factors in the pathogenesis of pediatric rhabdomysarcoma.
Cancer research - 1 Apr 1999
Barr F G
Abstract excerpt
Alveolar rhabdomyosarcoma (ARMS) is an aggressive pediatric soft tissue tumor with striated muscle differentiation. Chromosomal studies of these tumors identified 2;13 and 1;13 translocations. Using physical mapping and cloning strategies, we determined that t(2;13) and t(1;13) rearrange PAX3 and...
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