Article
High frequency of somatic mutations in the VH genes expressed in prolymphocytic leukemia.
Blood - 15 Nov 1996
Davi F, Maloum K, Michel A, Pritsch O, Magnac C, Macintyre E, Salomon-Nguyen F, Binet J L, Dighiero G, Merle-Béral H
Abstract excerpt
Prolymphocytic leukemia (PLL) is a chronic lymphoproliferative disorder, characterized by prominent splenomegaly, prolymphocytes accounting for more than 55% of circulating lymphocytes, and short-term survival. To better characterize the nature of the cellular origin in this disease, we analyzed lg heavy chain variable region (VH) genes in eleven cases of de novo PLL Leukemic cells expressed a skewed repertoire...
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