Transformation of Follicular Lymphoma to Plasmablastic Lymphoma With c-<i>myc</i> Gene Rearrangement

doi:10.1309/ajcpwy1sgj9ieaor

Article

Transformation of Follicular Lymphoma to Plasmablastic Lymphoma With c-<i>myc</i> Gene Rearrangement

18 Nov 2010

Abstract excerpt

Follicular lymphoma (FL) is an indolent lymphoma that transforms to high-grade lymphoma, mostly diffuse large B-cell lymphoma, in about a third of patients. We present the first report of a case of FL that transformed to plasmablastic lymphoma (PBL). Clonal transformation of the FL to PBL was evidenced by identical IGH/BCL2 gene rearrangements and VDJ gene usage in rearranged IGH genes. IGH/ BCL2 translocation...

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