Article
Kinesin heavy chain is essential for viability and neuromuscular functions in Drosophila, but mutants show no defects in mitosis.
Cell - 22 Mar 1991
Saxton W M, Hicks J, Goldstein L S, Raff E C
Abstract excerpt
The in vivo function of the microtubule motor protein kinesin was examined in Drosophila using genetics and immunolocalization. Kinesin heavy chain mutations (khc) cause abnormal behavior and lethality. Mutant larvae exhibit loss of mobility and tactile responsiveness in the most posterior segments, followed by general paralysis and death during larval or pupal development. Adults homozygous for a...
Topics
- Adenosine Triphosphatases
- Alleles
- Animals
- Drosophila
- Immunohistochemistry
- Kinesins
- Larva
- Microtubule Proteins
- Mitosis
- Motor Activity
- Mutation