Article
Mutations in the gyrA and parC genes in fluoroquinolone-resistant clinical isolates of Pseudomonas aeruginosa.
Antimicrobial agents and chemotherapy - 1 Oct 1997
Nakano M, Deguchi T, Kawamura T, Yasuda M, Kimura M, Okano Y, Kawada Y
Abstract excerpt
We determined partial sequences of the gyrA and parC genes of the fluoroquinolone-susceptible strain ATCC 27853 and 22 clinical isolates of Pseudomonas aeruginosa. While a single amino acid change in GyrA with or without a change in ParC was found in 14 isolates with decreased susceptibility to f...
Topics
- Amino Acid Sequence
- Anti-Infective Agents
- Base Sequence
- DNA, Bacterial
- Drug Resistance, Microbial
- Fluoroquinolones
- Genes, Bacterial
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Pseudomonas aeruginosa