Expression of an ornithine decarboxylase dominant-negative mutant reverses eukaryotic initiation factor 4E-induced cell transformation.

Article

Expression of an ornithine decarboxylase dominant-negative mutant reverses eukaryotic initiation factor 4E-induced cell transformation.

Cancer research - 15 Nov 1996

Shantz L M, Coleman C S, Pegg A E

Abstract excerpt

pMV7-4E cells (4E-P2), which overexpress translation initiation factor eIF-4E, contain elevated levels of ornithine decarboxylase (ODC), the first and rate-limiting enzyme in polyamine biosynthesis. We have shown previously that this induction appears to be related to the transformed phenotype of...

Topics

3T3 Cells
Animals
Cell Transformation, Neoplastic
Mice
Mice, Nude
Mutation
Ornithine Decarboxylase
Transcription Factors
Transfection
Tumor Stem Cell Assay

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