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Article

Expression of an ornithine decarboxylase dominant-negative mutant reverses eukaryotic initiation factor 4E-induced cell transformation.

Cancer research - 15 Nov 1996

Shantz L M, Coleman C S, Pegg A E

Abstract excerpt

pMV7-4E cells (4E-P2), which overexpress translation initiation factor eIF-4E, contain elevated levels of ornithine decarboxylase (ODC), the first and rate-limiting enzyme in polyamine biosynthesis. We have shown previously that this induction appears to be related to the transformed phenotype of these cells (L. M. Shantz and A. E. Pegg, Cancer Res., 54: 2313-2316, 1994). To test whether increased ODC activity is...

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PMID: 8912847

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