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Article

Phenotypic features of breast cancer cells overexpressing ornithine-decarboxylase.

Journal of cellular physiology - 1 Apr 1995

Manni A, Wechter R, Wei L, Heitjan D, Demers L

Abstract excerpt

Polyamines (PA) have been shown to be critical mediators of estradiol-induced breast cancer cell proliferation. This finding suggests that constitutive activation of the PA pathway may promote tumor progression, possibly leading to hormone independence. To test this hypothesis, we transfected hormone-responsive MCF-7 breast cancer cells with a complementary DNA coding for ornithine-decarboxylase (ODC), the first...

Topics

Breast Neoplasms
Clone Cells
Eflornithine
Ornithine Decarboxylase
Phenotype
Polyamines
Putrescine
Receptors, Estrogen
Receptors, Progesterone
Transfection
Tumor Cells, Cultured

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Identifiers

PMID: 7896889
DOI: 10.1002/jcp.1041630115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7896889-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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