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Article

Ornithine decarboxylase overexpression in mouse 10T1/2 fibroblasts: cellular transformation and invasion.

Journal of the National Cancer Institute - 16 Apr 1997

Kubota S, Kiyosawa H, Nomura Y, Yamada T, Seyama Y

Abstract excerpt

BACKGROUND: Ornithine decarboxylase (ODC) plays a pivotal role in the synthesis of polyamines, a group of chemical compounds that are essential for cell growth. Recent reports have shown that ODC overexpression may be involved in malignant transformation of immortalized NIH 3T3 cells. We have demonstrated that ODC-overproducing mouse breast cancer cells are more invasive in vitro than control cells. However,...

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Share to Calcium-Calmodulin-Dependent Protein Kinases
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9106645
DOI: 10.1093/jnci/89.8.567

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Ornithine decarboxylase overexpression in mouse 10T1/2 fibroblasts: cellular transformation and invasion.PMID 9106645Read ↗

Transformation of NIH/3T3 cells by ornithine decarboxylase overexpression.Semantic proximity Read ↗

K-FGF mediated transformation and induction of metastatic potential involves altered ornithine decarboxylase and S-adenosylmethionine decarboxylase expression--role in cellular invasion.Semantic proximity Read ↗

Ornithine decarboxylase is directly involved in mouse mammary carcinoma cell invasion in vitro.Semantic proximity Read ↗

Expression of an ornithine decarboxylase dominant-negative mutant reverses eukaryotic initiation factor 4E-induced cell transformation.Semantic proximity Read ↗

The polyamine metabolism genes <i>ornithine decarboxylase</i> and <i>antizyme 2</i> predict aggressive behavior in neuroblastomas with and without <i>MYCN</i> amplificationSemantic proximity Read ↗

Altered ornithine decarboxylase and S-adenosylmethionine decarboxylase expression and regulation in mouse fibroblasts transformed with oncogenes or constitutively active Mitogen-Activated Protein (MAP) kinase kinase.Semantic proximity Read ↗

Phenotypic features of breast cancer cells overexpressing ornithine-decarboxylase.Semantic proximity Read ↗

Induction of epithelial differentiation and DNA demethylation in hamster malignant oral keratinocyte by ornithine decarboxylase antizyme.Semantic proximity Read ↗

Polyamines induce malignant transformation in cultured NIH 3T3 fibroblasts.Semantic proximity Read ↗

Regulation of ornithine decarboxylase.Semantic proximity Read ↗

Targeting Ornithine Decarboxylase Impairs Development of <i>MYCN</i> -Amplified NeuroblastomaSemantic proximity Read ↗

TGFalpha is required for full expression of the transformed growth phenotype of NIH 3T3 cells overexpressing ornithine decarboxylase.Semantic proximity Read ↗

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