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Article

Ornithine decarboxylase overexpression in mouse 10T1/2 fibroblasts: cellular transformation and invasion.

Journal of the National Cancer Institute - 16 Apr 1997

Kubota S, Kiyosawa H, Nomura Y, Yamada T, Seyama Y

Abstract excerpt

BACKGROUND: Ornithine decarboxylase (ODC) plays a pivotal role in the synthesis of polyamines, a group of chemical compounds that are essential for cell growth. Recent reports have shown that ODC overexpression may be involved in malignant transformation of immortalized NIH 3T3 cells. We have dem...

Topics

Animals
Calcium-Calmodulin-Dependent Protein Kinases
Cell Transformation, Neoplastic
Female
Fibroblasts
Gene Expression Regulation, Enzymologic
Mammary Neoplasms, Experimental
Mice
Neoplasm Invasiveness
Ornithine Decarboxylase
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transfection

Up-Regulation

Source

Identifiers

PMID: 9106645
DOI: 10.1093/jnci/89.8.567

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9106645-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Ornithine decarboxylase overexpression in mouse 10T1/2 fibroblasts: cellular transformation and invasion.PMID 9106645Read ↗

Transformation of NIH/3T3 cells by ornithine decarboxylase overexpression.Semantic proximity Read ↗

K-FGF mediated transformation and induction of metastatic potential involves altered ornithine decarboxylase and S-adenosylmethionine decarboxylase expression--role in cellular invasion.Semantic proximity Read ↗

Ornithine decarboxylase is directly involved in mouse mammary carcinoma cell invasion in vitro.Semantic proximity Read ↗

Expression of an ornithine decarboxylase dominant-negative mutant reverses eukaryotic initiation factor 4E-induced cell transformation.Semantic proximity Read ↗

The polyamine metabolism genes <i>ornithine decarboxylase</i> and <i>antizyme 2</i> predict aggressive behavior in neuroblastomas with and without <i>MYCN</i> amplificationSemantic proximity Read ↗

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Polyamines induce malignant transformation in cultured NIH 3T3 fibroblasts.Semantic proximity Read ↗

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Targeting Ornithine Decarboxylase Impairs Development of <i>MYCN</i> -Amplified NeuroblastomaSemantic proximity Read ↗

TGFalpha is required for full expression of the transformed growth phenotype of NIH 3T3 cells overexpressing ornithine decarboxylase.Semantic proximity Read ↗

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