Article
Differentiation of a mouse neuroblastoma variant cell line whose ornithine decarboxylase gene has been amplified.
Biochimica et biophysica acta - 3 Dec 1991
Chen Z P, Chen K Y
Abstract excerpt
Differentiation of mouse neuroblastoma cells has been shown to be accompanied by changes in polyamine metabolism and a decrease in polyamine content. We have previously shown that alpha-difluoromethyl ornithine, a suicide inhibitor of ornithine decarboxylase (ODC, EC 4.1.1.17) and suboptimal conc...
Topics
- Acetylcholinesterase
- Animals
- Bucladesine
- Cell Differentiation
- Cell Line
- Drug Resistance
- Eflornithine
- Enzyme Induction
- Gene Amplification
- Genetic Variation
- Mice
- Neuroblastoma
- Ornithine Decarboxylase