Article
Transformation of NIH/3T3 cells by ornithine decarboxylase overexpression.
Cancer research - 1 Jun 1993
Moshier J A, Dosescu J, Skunca M, Luk G D
Abstract excerpt
Ornithine decarboxylase (ODC) plays a rate-limiting role in polyamine biosynthesis and is intimately associated with cell proliferation and function. Although elevated levels of ODC mRNA, protein, and enzyme activity are consistently detected in transformed cells and tumors, the question remains...
Topics
- 3T3 Cells
- Actins
- Animals
- Cell Division
- Cell Transformation, Neoplastic
- Gene Expression Regulation, Enzymologic
- Mice
- Ornithine Decarboxylase
- Phenotype
- Plasmids
- RNA, Messenger
- Transfection