Article
Eflornithine (DFMO) prevents progression of pancreatic cancer by modulating ornithine decarboxylase signaling.
Cancer prevention research (Philadelphia, Pa.) - 1 Dec 2014
Mohammed Altaf, Janakiram Naveena B, Madka Venkateshwar, Ritchie Rebekah L, Brewer Misty, Biddick Laura, Patlolla Jagan Mohan R, Sadeghi Michael, Lightfoot Stan, Steele Vernon E, Rao Chinthalapally V
Abstract excerpt
Ornithine decarboxylase (ODC) is the key rate-limiting enzyme in the polyamine synthesis pathway and it is overexpressed in a variety of cancers. We found that polyamine synthesis and modulation of ODC signaling occurs at early stages of pancreatic precursor lesions and increases as the tumor progresses in Kras-activated p48(Cre/+)-LSL-Kras(G12D/+) mice. Interest in use of the ODC inhibitor eflornithine (DFMO) as...
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