Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene.

doi:10.1126/science.1350108

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Article

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene.

Science (New York, N.Y.) - 1 May 1992

Su L K, Kinzler K W, Vogelstein B, Preisinger A C, Moser A R, Luongo C, Gould K A, Dove W F

Abstract excerpt

Germ-line mutations of the APC gene are responsible for familial adenomatous polyposis (FAP), an autosomal dominantly inherited disease in humans. Patients with FAP develop multiple benign colorectal tumors. Recently, a mouse lineage that exhibits an autosomal dominantly inherited predisposition to multiple intestinal neoplasia (Min) was described. Linkage analysis showed that the murine homolog of the APC gene...

Topics

Adenomatous Polyposis Coli
Animals
Base Sequence
Blotting, Southern
Colorectal Neoplasms
DNA, Neoplasm
Genes, Tumor Suppressor
Genetic Linkage
Humans
Intestinal Neoplasms
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred AKR

Mice, Inbred BALB C

Mice, Inbred C57BL

Molecular Sequence Data

Mutation

Phenotype

Polymorphism, Restriction Fragment Length

Source

Open in PubMed

Identifiers

PMID: 1350108
DOI: 10.1126/science.1350108

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1350108-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene.PMID 1350108Read ↗

Mapping of multiple intestinal neoplasia (Min) to proximal chromosome 18 of the mouse.Semantic proximity Read ↗

Generation of a unique strain of multiple intestinal neoplasia (Apc+/Min‐FCCC) mice with significantly increased numbers of colorectal adenomasSemantic proximity Read ↗

Multistep carcinogenesis of the colon in Apc(Min/+) mouse.Semantic proximity Read ↗

Genetic mapping of novel modifiers for ApcMin induced intestinal polyps’ development using the genetic architecture power of the collaborative cross miceSemantic proximity Read ↗

Genetic analysis of intestinal polyp development in Collaborative Cross mice carrying the Apc (Min/+) mutation.Semantic proximity Read ↗

Complete deletion of Apc results in severe polyposis in mice.Semantic proximity Read ↗

ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias.Semantic proximity Read ↗

Identification of Mom7, a novel modifier of Apc(Min/+) on mouse chromosome 18.Semantic proximity Read ↗

The development of duodenal microadenomas in FAP patients: the human correlate of the Min mouse.Semantic proximity Read ↗

The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia.Semantic proximity Read ↗

Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis.Semantic proximity Read ↗

The pleiotropic phenotype of Apc mutations in the mouse: allele specificity and effects of the genetic background.Semantic proximity Read ↗

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