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Article

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene.

Science (New York, N.Y.) - 1 May 1992

Su L K, Kinzler K W, Vogelstein B, Preisinger A C, Moser A R, Luongo C, Gould K A, Dove W F

Abstract excerpt

Germ-line mutations of the APC gene are responsible for familial adenomatous polyposis (FAP), an autosomal dominantly inherited disease in humans. Patients with FAP develop multiple benign colorectal tumors. Recently, a mouse lineage that exhibits an autosomal dominantly inherited predisposition to multiple intestinal neoplasia (Min) was described. Linkage analysis showed that the murine homolog of the APC gene...

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Source

Identifiers

PMID: 1350108
DOI: 10.1126/science.1350108

Genes

APC
FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene.PMID 1350108Read ↗

Mapping of multiple intestinal neoplasia (Min) to proximal chromosome 18 of the mouse.Semantic proximity Read ↗

Generation of a unique strain of multiple intestinal neoplasia (Apc+/Min‐FCCC) mice with significantly increased numbers of colorectal adenomasSemantic proximity Read ↗

Multistep carcinogenesis of the colon in Apc(Min/+) mouse.Semantic proximity Read ↗

Genetic mapping of novel modifiers for ApcMin induced intestinal polyps’ development using the genetic architecture power of the collaborative cross miceSemantic proximity Read ↗

Genetic analysis of intestinal polyp development in Collaborative Cross mice carrying the Apc (Min/+) mutation.Semantic proximity Read ↗

Complete deletion of Apc results in severe polyposis in mice.Semantic proximity Read ↗

ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias.Semantic proximity Read ↗

Identification of Mom7, a novel modifier of Apc(Min/+) on mouse chromosome 18.Semantic proximity Read ↗

The development of duodenal microadenomas in FAP patients: the human correlate of the Min mouse.Semantic proximity Read ↗

The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia.Semantic proximity Read ↗

Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis.Semantic proximity Read ↗

The pleiotropic phenotype of Apc mutations in the mouse: allele specificity and effects of the genetic background.Semantic proximity Read ↗

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