Article
To what extent is strain variation evidence for an independent genome in the agent of the transmissible spongiform encephalopathies?
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration - 1 Sept 1996
Ridley R M, Baker H F
Abstract excerpt
The apparent existence of multiple strains of the 'transmissible agent' associated with spongiform encephalopathy (prion disease) has been used to support the argument that these diseases are caused by an independent, replicating agent with its own genome. However, the length of the incubation period (time from injection of infected material to onset of clinical signs) and the lesion profile (regional...
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