Article
A pathway for targeting soluble misfolded proteins to the yeast vacuole.
The Journal of cell biology - 1 Nov 1996
Hong E, Davidson A R, Kaiser C A
Abstract excerpt
We have evaluated the fate of misfolded protein domains in the Saccharomyces cerevisiae secretory pathway by fusing mutant forms of the NH2-terminal domain of lambda repressor protein to the secreted protein invertase. The hybrid protein carrying the wild-type repressor domain is mostly secreted...
Topics
- Amino Acid Sequence
- Biological Transport
- DNA-Binding Proteins
- Endopeptidases
- Endoplasmic Reticulum
- Fungal Proteins
- Glycoside Hydrolases
- Molecular Sequence Data
- Mutation
- Protein Folding
- Receptors, Cell Surface
- Recombinant Fusion Proteins
- Repressor Proteins
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Solubility
- Vacuoles
- Vesicular Transport Proteins