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Article

Signal recognition particle receptor is important for cell growth and protein secretion in Saccharomyces cerevisiae.

Molecular biology of the cell - 1 Aug 1992

Ogg S C, Poritz M A, Walter P

Abstract excerpt

In mammalian cells, the signal recognition particle (SRP) receptor is required for the targeting of nascent secretory proteins to the endoplasmic reticulum (ER) membrane. We have identified the Saccharomyces cerevisiae homologue of the alpha-subunit of the SRP receptor (SR alpha) and characterized its function in vivo. S. cerevisiae SR alpha is a 69-kDa peripheral membrane protein that is 32% identical (54%...

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Identifiers

PMID: 1327299
DOI: 10.1091/mbc.3.8.895
PMCID: PMC275647

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Signal recognition particle receptor is important for cell growth and protein secretion in Saccharomyces cerevisiae.PMID 1327299Read ↗

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An interaction between the SRP receptor and the translocon is critical during cotranslational protein translocation.Semantic proximity Read ↗

Signal sequences specify the targeting route to the endoplasmic reticulum membrane.Semantic proximity Read ↗

ARL1 and membrane traffic in Saccharomyces cerevisiae.Semantic proximity Read ↗

Elongation arrest is a physiologically important function of signal recognition particle.Semantic proximity Read ↗

Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo.Semantic proximity Read ↗

Receptor internalization in yeast requires the Tor2-Rho1 signaling pathway.Semantic proximity Read ↗

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The beta-subunit of the signal recognition particle receptor is a novel GTP-binding protein without intrinsic GTPase activity.Semantic proximity Read ↗

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